/* ============================================================
   A Vaccine Built for One — design system
   Territory: clinical-hope — sterile white pierced by mRNA-strand
   colour, patient-outcome warmth; serious medicine, human stakes.
   ============================================================ */

@font-face{font-family:'Fraunces';src:url('../fonts/Fraunces-300-700-normal.woff2') format('woff2');font-weight:300 700;font-style:normal;font-display:swap}
@font-face{font-family:'Fraunces';src:url('../fonts/Fraunces-300-700-italic.woff2') format('woff2');font-weight:300 700;font-style:italic;font-display:swap}
@font-face{font-family:'Inter';src:url('../fonts/Inter-400-800-normal.woff2') format('woff2');font-weight:400 800;font-style:normal;font-display:swap}
@font-face{font-family:'Plex Mono';src:url('../fonts/IBMPlexMono-400-normal.woff2') format('woff2');font-weight:400;font-style:normal;font-display:swap}
@font-face{font-family:'Plex Mono';src:url('../fonts/IBMPlexMono-400-italic.woff2') format('woff2');font-weight:400;font-style:italic;font-display:swap}
@font-face{font-family:'Plex Mono';src:url('../fonts/IBMPlexMono-500-normal.woff2') format('woff2');font-weight:500;font-style:normal;font-display:swap}
@font-face{font-family:'Plex Mono';src:url('../fonts/IBMPlexMono-600-normal.woff2') format('woff2');font-weight:600;font-style:normal;font-display:swap}

:root{
  --paper:#FAFBFC;
  --panel:#FFFFFF;
  --ink:#0C1B2A;
  --ink-2:#33475C;
  --muted:#64748B;
  --hairline:#E3E9F0;
  --strand:#0E9594;
  --strand-bright:#14B8C4;
  --strand-deep:#0B6E72;
  --strand-wash:#E7F4F4;
  --warm:#D97E36;
  --warm-deep:#B4552D;
  --warm-wash:#FBF3E4;
  --warm-soft:#F6E3C5;
  --slate:#8CA3B8;
  --shadow:0 1px 2px rgba(12,27,42,.05),0 12px 32px -12px rgba(12,27,42,.12);
  --shadow-lg:0 2px 4px rgba(12,27,42,.06),0 24px 56px -16px rgba(12,27,42,.18);
  --radius:16px;
  --wrap:72rem;
  --font-display:'Fraunces',Georgia,'Times New Roman',serif;
  --font-body:'Inter',-apple-system,'Segoe UI',sans-serif;
  --font-mono:'Plex Mono','SFMono-Regular',Consolas,monospace;
}

*,*::before,*::after{box-sizing:border-box}
html{scroll-behavior:smooth}
body{
  margin:0;
  background:var(--paper);
  color:var(--ink-2);
  font-family:var(--font-body);
  font-size:1.0625rem;
  line-height:1.68;
  -webkit-font-smoothing:antialiased;
  text-rendering:optimizeLegibility;
  overflow-x:hidden;
}
/* faint clinical grid on the paper */
body::before{
  content:"";position:fixed;inset:0;pointer-events:none;z-index:0;
  background-image:
    linear-gradient(var(--hairline) 1px,transparent 1px),
    linear-gradient(90deg,var(--hairline) 1px,transparent 1px);
  background-size:88px 88px;
  opacity:.32;
}
main{position:relative;z-index:1}

h1,h2,h3,h4,h5{font-family:var(--font-display);color:var(--ink);line-height:1.12;font-weight:560;letter-spacing:-.01em}
h1{font-size:clamp(2.9rem,7.4vw,5.6rem);font-weight:480;letter-spacing:-.022em;margin:.35em 0 .3em}
h1 em{font-style:italic;color:var(--strand);font-weight:560}
h2{font-size:clamp(1.9rem,4.2vw,3.1rem);font-weight:520;margin:.25em 0 .35em}
h2 em{font-style:italic;color:var(--strand)}
h3{font-size:1.35rem;margin:0 0 .6em}
h4{font-size:1.08rem;font-family:var(--font-body);font-weight:700;letter-spacing:0;margin:0 0 .7em}
h5{font-size:.98rem;font-family:var(--font-body);font-weight:700;margin:0 0 .45em}
p{margin:0 0 1.1em}
strong{color:var(--ink);font-weight:650}
em{font-style:italic}
a{color:var(--strand-deep);text-decoration:none;border-bottom:1px solid rgba(14,149,148,.35);transition:border-color .2s,color .2s}
a:hover{color:var(--strand);border-bottom-color:var(--strand)}
sup{font-size:.68em;line-height:0}
sup a{border:none;color:var(--strand);font-weight:600;padding:0 .05em}
.mono{font-family:var(--font-mono);font-weight:500;letter-spacing:-.01em}
.fineprint{font-size:.86rem;color:var(--muted);line-height:1.6}
.center-note{max-width:56rem;margin:1.6rem auto 0;text-align:center}
.h-inline{font-size:1.22rem;margin-top:1.4em}
.h-inline:first-child{margin-top:0}
ul,ol{padding-left:1.3em}
li{margin-bottom:.5em}
img,svg{max-width:100%;height:auto}
button{font:inherit}

/* ---------- a11y ---------- */
.skip-link{
  position:fixed;top:-60px;left:16px;z-index:100;background:var(--ink);color:#fff;
  padding:.6rem 1rem;border-radius:8px;font-size:.85rem;border:none;transition:top .2s;
}
.skip-link:focus{top:12px;color:#fff}

/* ---------- progress + topbar ---------- */
.progress{position:fixed;top:0;left:0;right:0;height:3px;z-index:60;background:transparent}
.progress span{display:block;height:100%;width:0;background:linear-gradient(90deg,var(--strand),var(--strand-bright));transition:width .12s linear}
.topbar{
  position:sticky;top:0;z-index:50;
  display:flex;align-items:center;gap:1.6rem;
  padding:.72rem clamp(1rem,4vw,2.4rem);
  background:rgba(250,251,252,.82);
  backdrop-filter:blur(14px);-webkit-backdrop-filter:blur(14px);
  border-bottom:1px solid var(--hairline);
}
.brand{display:flex;align-items:center;gap:.6rem;border:none;color:var(--ink);flex:none}
.brand-mark{width:26px;height:26px;color:var(--strand);flex:none}
.brand-text{font-family:var(--font-display);font-weight:600;font-size:1.02rem;letter-spacing:-.01em;white-space:nowrap;display:flex;flex-direction:column;line-height:1.1}
.brand-text em{font-style:normal;font-family:var(--font-mono);font-size:.6rem;letter-spacing:.14em;text-transform:uppercase;color:var(--muted)}
.topnav{display:flex;gap:.15rem;margin-left:auto;flex:0 1 auto;min-width:0;overflow-x:auto;scrollbar-width:none}
.topnav::-webkit-scrollbar{display:none}
.topnav a{
  font-size:.8rem;font-weight:550;color:var(--ink-2);border:none;white-space:nowrap;
  padding:.42rem .68rem;border-radius:99px;transition:background .18s,color .18s;
}
.topnav a:hover{background:var(--strand-wash);color:var(--strand-deep)}
.topnav a.active{background:var(--ink);color:#fff}
.topdate{font-family:var(--font-mono);font-size:.72rem;color:var(--muted);border:1px solid var(--hairline);border-radius:99px;padding:.3rem .7rem;white-space:nowrap;flex:none}

/* ---------- hero ---------- */
.hero{
  position:relative;overflow:hidden;
  min-height:min(92vh,56rem);
  display:flex;align-items:center;
  border-bottom:1px solid var(--hairline);
}
.hero-strand{position:absolute;inset:0;pointer-events:none}
.hero-strand svg{width:100%;height:100%}
.hx{fill:none;stroke:url(#strandGrad);stroke-width:2.6;stroke-linecap:round}
.hx-b{opacity:.85}
.helix-2 .hx{stroke-width:1.4}
.rungs line{stroke:var(--strand);stroke-width:1.4;opacity:.5;stroke-linecap:round}
.hero-inner{
  position:relative;max-width:var(--wrap);margin:0 auto;
  padding:clamp(3rem,8vh,6rem) clamp(1.2rem,4vw,2.4rem);
}
.kicker{
  display:inline-flex;flex-wrap:wrap;align-items:center;justify-content:center;gap:.3rem .6rem;
  font-family:var(--font-mono);font-size:.78rem;letter-spacing:.1em;text-transform:uppercase;line-height:1.6;
  color:var(--ink-2);background:rgba(255,255,255,.75);border:1px solid var(--hairline);
  padding:.5rem 1rem;border-radius:99px;box-shadow:var(--shadow);
}
.dot{width:8px;height:8px;border-radius:50%;flex:none}
.dot-teal{background:var(--strand);box-shadow:0 0 0 4px var(--strand-wash)}
.lede{max-width:44rem;font-size:clamp(1.08rem,1.9vw,1.3rem);line-height:1.62;color:var(--ink-2);margin:1.4rem 0 0;text-wrap:pretty}
.hero-stats{
  display:flex;flex-wrap:wrap;gap:0;margin:2.4rem 0 0;
  background:rgba(255,255,255,.85);border:1px solid var(--hairline);border-radius:var(--radius);
  box-shadow:var(--shadow);overflow:hidden;max-width:56rem;
}
.hstat{flex:1 1 10rem;padding:1.15rem 1.3rem;border-right:1px solid var(--hairline)}
.hstat:last-child{border-right:none}
.hstat-num{display:block;font-size:clamp(1.7rem,3vw,2.3rem);font-weight:600;color:var(--ink);line-height:1;font-variant-numeric:tabular-nums}
.hstat-num sup{font-size:.45em;color:var(--strand);font-weight:700}
.hstat-first .hstat-num{color:var(--strand-deep)}
.hstat-label{display:block;margin-top:.55rem;font-size:.78rem;line-height:1.45;color:var(--muted)}
.hero-verdicts{display:flex;flex-wrap:wrap;gap:.6rem;margin-top:1.4rem}
.verdict{
  display:inline-flex;align-items:center;gap:.5rem;
  font-size:.82rem;font-weight:600;padding:.5rem .9rem;border-radius:99px;
}
.verdict svg{width:14px;height:14px;flex:none}
.verdict-met{background:var(--strand-wash);color:var(--strand-deep);border:1px solid rgba(14,149,148,.3)}
.verdict-pending{background:var(--warm-wash);color:var(--warm-deep);border:1px solid rgba(217,126,54,.35)}
.scrollcue{
  display:inline-flex;align-items:center;gap:.6rem;margin-top:2.6rem;
  font-family:var(--font-mono);font-size:.76rem;letter-spacing:.12em;text-transform:uppercase;
  color:var(--muted);border:none;
}
.scrollcue svg{width:18px;height:18px;color:var(--strand);animation:cue 2.2s ease-in-out infinite}
@keyframes cue{0%,100%{transform:translateY(0)}50%{transform:translateY(6px)}}
.scrollcue:hover{color:var(--strand-deep)}

/* ---------- chapters ---------- */
.chapter{
  max-width:var(--wrap);margin:0 auto;
  padding:clamp(3.4rem,9vh,6.5rem) clamp(1.2rem,4vw,2.4rem) clamp(2.6rem,6vh,4.5rem);
}
.chapter + .chapter{border-top:1px solid var(--hairline)}
.chapter-warm{
  max-width:none;
  background:
    radial-gradient(1200px 400px at 85% 0%,rgba(217,126,54,.07),transparent 65%),
    linear-gradient(180deg,#FDFAF4 0%,var(--paper) 100%);
}
.chapter-warm > *{max-width:var(--wrap);margin-left:auto;margin-right:auto}
.chapter-dark{
  max-width:none;
  background:linear-gradient(180deg,#0C1B2A 0%,#10253A 78%,var(--paper) 100%);
  color:#C8D6E2;
}
.chapter-dark > *{max-width:var(--wrap);margin-left:auto;margin-right:auto}
.chapter-dark h2,.chapter-dark h5{color:#F4F8FB}
.chapter-dark .ch-kicker{color:var(--strand-bright)}
.chapter-dark .ch-num{color:rgba(20,184,196,.35);border-color:rgba(20,184,196,.25)}
.chapter-dark .ch-sub{color:#9FB4C6}
.chapter-dark p{color:#C8D6E2}
.chapter-dark strong{color:#fff}
.chapter-dark figcaption{color:#8FA5B8}
.chapter-dark a{color:var(--strand-bright);border-bottom-color:rgba(20,184,196,.45)}
.chapter-dark a:hover{color:#7BE3EA}

.ch-head{max-width:56rem;margin-bottom:clamp(1.8rem,4vh,3rem);position:relative}
.ch-num{
  position:absolute;right:0;top:-.4rem;
  font-size:clamp(3rem,7vw,4.6rem);font-weight:400;color:rgba(12,27,42,.08);
  border-bottom:2px solid var(--hairline);line-height:1;padding-bottom:.2rem;
}
.ch-kicker{
  font-family:var(--font-mono);font-size:.74rem;letter-spacing:.18em;text-transform:uppercase;
  color:var(--strand-deep);margin:0 0 .5rem;
}
.ch-sub{font-size:clamp(1rem,1.7vw,1.16rem);color:var(--ink-2);max-width:46rem;text-wrap:pretty}

.grid-2{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1fr);gap:clamp(1.4rem,3.5vw,2.6rem);align-items:start}
.grid-3{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:1.2rem;margin-top:2rem}

/* ---------- cards ---------- */
.card{
  background:var(--panel);border:1px solid var(--hairline);border-radius:var(--radius);
  padding:clamp(1.3rem,2.6vw,1.9rem);box-shadow:var(--shadow);
}
.card h4{display:flex;align-items:center;gap:.55rem}
.card-news p:first-of-type{margin-top:.2em}
.arms-mini{list-style:none;padding:0;margin:1.1rem 0;display:grid;gap:.7rem}
.arms-mini li{display:flex;gap:.85rem;align-items:flex-start;margin:0}
.arm-chip{
  flex:none;width:30px;height:30px;border-radius:9px;display:grid;place-items:center;
  font-family:var(--font-mono);font-weight:600;font-size:.85rem;margin-top:.1rem;
}
.arm-a{background:var(--strand-wash);color:var(--strand-deep);border:1px solid rgba(14,149,148,.4)}
.arm-b{background:#EEF2F6;color:var(--ink-2);border:1px solid var(--hairline)}
.endpoint-list{margin:1rem 0;display:grid;gap:.9rem}
.endpoint-list dt{font-weight:650;color:var(--ink);display:flex;align-items:center;gap:.6rem;flex-wrap:wrap}
.endpoint-list dd{margin:.3rem 0 0;color:var(--ink-2)}
.tag{
  font-family:var(--font-mono);font-size:.64rem;letter-spacing:.08em;text-transform:uppercase;
  padding:.22rem .55rem;border-radius:99px;font-weight:600;white-space:nowrap;
}
.tag-met{background:var(--strand-wash);color:var(--strand-deep);border:1px solid rgba(14,149,148,.35)}
.tag-pending,.ledger-tag.tag-pending{background:var(--warm-wash);color:var(--warm-deep);border:1px solid rgba(217,126,54,.4)}
.tag-known,.ledger-tag.tag-known{background:var(--strand-wash);color:var(--strand-deep);border:1px solid rgba(14,149,148,.35)}

.card-quote{
  background:linear-gradient(135deg,#0E3A40,#0C2A33);
  border-color:rgba(20,184,196,.25);color:#DCEBEE;margin-bottom:1.2rem;
}
.card-quote blockquote{
  margin:0;font-family:var(--font-display);font-size:1.22rem;font-style:italic;
  line-height:1.5;color:#F2F7F8;
}
.card-quote figcaption{margin-top:1.1rem;display:flex;flex-direction:column;gap:.15rem}
.card-quote figcaption strong{color:#fff;font-size:.92rem}
.card-quote figcaption span{font-size:.78rem;color:#8FB9BE}
.card-nodisclose{border-left:3px solid var(--warm)}
.card-nodisclose h4{color:var(--warm-deep)}
.card-nodisclose svg{width:18px;height:18px;flex:none}

/* ---------- stat cards ---------- */
.statcards{display:grid;grid-template-columns:1fr 1fr;gap:1rem}
.scard{
  background:var(--panel);border:1px solid var(--hairline);border-radius:var(--radius);
  padding:1.15rem 1.2rem;box-shadow:var(--shadow);
}
.scard-num{display:block;font-size:clamp(1.5rem,2.6vw,2rem);font-weight:600;color:var(--warm-deep);line-height:1.05;font-variant-numeric:tabular-nums}
.scard-label{display:block;margin-top:.5rem;font-size:.8rem;line-height:1.45;color:var(--muted)}
.scard-label sup a{color:var(--warm)}

.pullquote{
  font-family:var(--font-display);font-size:clamp(1.12rem,1.9vw,1.32rem);font-style:italic;
  line-height:1.55;color:var(--ink);border-left:3px solid var(--warm);
  padding:.2rem 0 .2rem 1.1rem;margin:1.6rem 0;
}
.pullquote cite{
  display:block;margin-top:.7rem;font-family:var(--font-body);font-style:normal;
  font-size:.82rem;color:var(--muted);
}

/* ---------- figures ---------- */
.fig{margin:2.4rem 0}
.fig svg,.card svg{display:block}
.fig-hint{display:none}
@media (max-width:820px){
  .fig-scroll{overflow-x:auto;-webkit-overflow-scrolling:touch;padding-bottom:.4rem}
  .fig-scroll svg{min-width:720px}
  .card-chart .fig-scroll svg{min-width:420px}
  .fig-scroll .prog-table{min-width:560px}
  .fig-hint{display:inline-block;font-family:var(--font-mono);font-size:.66rem;letter-spacing:.08em;
    color:var(--strand-deep);margin-right:.8rem;background:var(--strand-wash);
    border:1px solid rgba(14,149,148,.3);border-radius:99px;padding:.15rem .6rem;vertical-align:.1em}
}
figcaption{font-size:.82rem;color:var(--muted);margin-top:.9rem;line-height:1.55;max-width:52rem}
.svg-label{font-family:var(--font-mono);font-size:12.5px;fill:var(--muted);letter-spacing:.04em}
.svg-stage-name{font-family:var(--font-body);font-size:17px;font-weight:700;fill:var(--ink)}
.svg-stage-sub{font-size:12.5px;fill:var(--muted)}
.svg-note{font-size:12px;fill:var(--muted)}
.svg-note-strong{font-size:12.5px;font-weight:650;fill:var(--ink)}
.svg-tiny{font-family:var(--font-mono);font-size:10.5px;fill:var(--muted)}
.svg-row{font-family:var(--font-mono);font-size:11.5px;fill:var(--ink-2);font-weight:500}
.svg-val{font-size:12px;fill:var(--ink);font-weight:600}
.svg-big{font-size:38px;fill:var(--ink);font-weight:600}
.svg-mid{font-size:26px;fill:var(--ink);font-weight:600}
.svg-arm-title{font-size:14px;font-weight:700;fill:var(--ink)}
.svg-cell-label{font-size:11px;fill:var(--muted)}
.stage-box{fill:#fff;stroke:var(--hairline);stroke-width:1.2}
.skin{fill:var(--warm-soft)}
.tumor{fill:#E9B9A0;stroke:var(--warm-deep);stroke-width:1.4}
.tumor-core{fill:var(--warm-deep)}
.node{fill:#EAF0F5;stroke:var(--slate);stroke-width:1.2}
.node-lit{fill:#F8D9B8;stroke:var(--warm-deep)}
.node-link{stroke:var(--slate);stroke-width:1.4;fill:none}
.organ{fill:#EDF2F7;stroke:var(--slate);stroke-width:1.2}
.arrow{stroke:var(--slate);stroke-width:1.8;fill:none;stroke-linecap:round;stroke-linejoin:round}
.arrow-teal{stroke:var(--strand)}
.sup-in{font-size:.7em}

/* ---------- mechanism cards ---------- */
.mech-grid .card-mech{padding-bottom:1.1rem}
.card-mech h4{font-size:.95rem;display:flex;align-items:center;gap:.6rem}
.mech-num{
  width:26px;height:26px;border-radius:8px;flex:none;
  background:var(--strand-wash);color:var(--strand-deep);border:1px solid rgba(14,149,148,.4);
  display:grid;place-items:center;font-size:.8rem;
}
.card-mech svg{background:linear-gradient(180deg,#FCFDFE,#F6F9FB);border:1px solid var(--hairline);border-radius:12px;margin-bottom:1rem}
.cell-body{fill:#fff;stroke:var(--slate);stroke-width:1.6}
.cell-nucleus{fill:#EAF0F5;stroke:none}
.tcell .cell-body{stroke:var(--strand)}
.tcell2 .cell-body{stroke:var(--strand)}
.tumorcell .cell-body{stroke:var(--warm-deep)}
.microtumor .cell-body{stroke:var(--warm-deep);fill:#FDF6EF}
.pd1{fill:#DCE8F0;stroke:var(--ink-2);stroke-width:1}
.pdl1{fill:#F8D9B8;stroke:var(--warm-deep);stroke-width:1}
.yab{stroke:var(--strand);stroke-width:2.4;fill:none;stroke-linecap:round}
.mrna-line{stroke:var(--strand);stroke-width:2.2;fill:none;stroke-linecap:round}
.flag{fill:var(--strand)}
.flag-surface{stroke:var(--warm-deep);stroke-width:2;fill:none;stroke-linecap:round}
.card-mech p{font-size:.94rem;margin:0}

/* wanted poster */
.wanted{
  display:grid;grid-template-columns:auto 1fr;gap:clamp(1.6rem,4vw,3rem);
  align-items:center;margin-top:clamp(2rem,5vh,3.4rem);
  background:var(--panel);border:1px solid var(--hairline);border-radius:var(--radius);
  padding:clamp(1.6rem,3.5vw,2.6rem);box-shadow:var(--shadow);
}
.wanted-poster{
  width:200px;flex:none;background:#FDFAF2;border:1.5px solid #D8C9A8;border-radius:6px;
  padding:1rem .9rem;text-align:center;transform:rotate(-2deg);
  box-shadow:0 10px 26px -10px rgba(12,27,42,.25);position:relative;
}
.wanted-poster::before{
  content:"";position:absolute;top:-9px;left:50%;transform:translateX(-50%) rotate(4deg);
  width:44px;height:16px;background:rgba(20,184,196,.35);border:1px solid rgba(14,149,148,.3);
}
.wp-head{font-size:1.5rem;font-weight:600;letter-spacing:.3em;color:#5C4A22;border-bottom:1.5px solid #D8C9A8;padding-bottom:.4rem}
.wp-face{display:flex;justify-content:center;gap:.45rem;margin:.9rem 0 .5rem}
.wp-face span{
  width:34px;height:44px;border-radius:50% 50% 46% 46%;
  background:linear-gradient(180deg,#F3E3C2,#E4CD9F);border:1.4px solid #B49B66;
  position:relative;
}
.wp-face span::before,.wp-face span::after{
  content:"";position:absolute;top:16px;width:4px;height:4px;border-radius:50%;background:#5C4A22;
}
.wp-face span::before{left:8px}.wp-face span::after{right:8px}
.wp-lines{display:grid;gap:5px;margin:.7rem .4rem}
.wp-lines i{height:5px;background:#E4CD9F;border-radius:3px}
.wp-lines i:nth-child(2){width:82%}
.wp-sub{font-size:.58rem;letter-spacing:.06em;color:#7A6433;margin-top:.5rem}
.wanted-copy .pullquote{margin-top:0;border-color:var(--strand)}
.wanted-copy cite{display:block;font-size:.82rem;color:var(--muted);margin-bottom:1rem}

/* ---------- pipeline (dark) ---------- */
.pipeline{margin:2rem 0 0}
.pipe{
  list-style:none;padding:0;margin:0;
  display:grid;grid-template-columns:repeat(6,minmax(0,1fr));gap:1rem;
}
.pipe-step{
  background:rgba(255,255,255,.05);border:1px solid rgba(160,190,210,.16);
  border-radius:14px;padding:1.1rem 1rem;position:relative;
  transition:transform .35s ease,border-color .35s ease,background .35s ease;
}
.pipe-step:hover{transform:translateY(-4px);border-color:rgba(20,184,196,.5);background:rgba(20,184,196,.07)}
.pipe-step h5{color:#F4F8FB;font-size:.86rem}
.pipe-step p{font-size:.78rem;line-height:1.55;color:#9FB4C6;margin:0}
.pipe-icon{
  width:46px;height:46px;border-radius:12px;display:grid;place-items:center;
  background:rgba(20,184,196,.12);border:1px solid rgba(20,184,196,.3);
  color:var(--strand-bright);margin-bottom:.8rem;
}
.pipe-icon svg{width:28px;height:28px}
.pipe-track{height:5px;border-radius:99px;background:rgba(160,190,210,.18);margin-top:1.6rem;overflow:hidden}
.pipe-fill{height:100%;width:0;border-radius:99px;background:linear-gradient(90deg,var(--strand-deep),var(--strand-bright));transition:width 1.6s cubic-bezier(.3,.7,.3,1)}
.pipe-scale{display:flex;justify-content:space-between;font-size:.72rem;color:#8FA5B8;margin-top:.55rem}
.pipeline figcaption{color:#8FA5B8}
.minicard{
  background:rgba(255,255,255,.05);border:1px solid rgba(160,190,210,.16);
  border-radius:14px;padding:1.2rem 1.2rem;
}
.minicard-num{display:block;font-size:1.5rem;font-weight:600;color:var(--strand-bright);margin-bottom:.5rem}
.minicard p{font-size:.85rem;margin:0;color:#B9CBD9}

/* ---------- datacuts (evidence section) ---------- */
.datacuts{list-style:none;padding:0;margin:1.2rem 0;display:grid;gap:.6rem}
.datacuts li{
  display:flex;flex-wrap:wrap;row-gap:.15rem;column-gap:.8rem;align-items:baseline;margin:0;min-width:0;
  background:var(--panel);border:1px solid var(--hairline);border-radius:10px;
  padding:.65rem .9rem;font-size:.9rem;line-height:1.5;box-shadow:var(--shadow);
}
.dc-time{
  flex:none;width:3.9rem;color:var(--strand-deep);font-weight:600;font-size:.74rem;
  letter-spacing:.04em;
}

/* ---------- HR chart ---------- */
.card-chart h4{margin-bottom:1rem}
.axis{stroke:var(--hairline);stroke-width:1.4}
.axis-ref{stroke:var(--warm);stroke-width:1.4;stroke-dasharray:4 4}
.whisker{stroke:var(--slate);stroke-width:2}
.whisker-miss{stroke:#C9B08C}
.cap{fill:#DCE6EE}
.cap-miss{fill:#EAD9BD}
.pt{stroke:#fff;stroke-width:2}
.pt-teal{fill:var(--strand)}
.pt-amber{fill:var(--warm)}
.hr-explainer{
  margin-top:2rem;background:var(--panel);border:1px solid var(--hairline);
  border-radius:var(--radius);padding:clamp(1.3rem,2.6vw,1.9rem);box-shadow:var(--shadow);
}
.hr-bars{display:grid;gap:.55rem;margin:1rem 0 1.2rem}
.hr-bar-row{display:grid;grid-template-columns:9.5rem minmax(0,1fr);align-items:center;gap:1rem}
.hr-bar-label{font-size:.8rem;font-weight:600;color:var(--ink-2);text-align:right}
.hr-bar{background:#F1F5F9;border-radius:8px;height:32px;overflow:hidden}
.hr-fill{
  display:inline-flex;align-items:center;justify-content:flex-end;
  height:100%;width:var(--w);border-radius:8px;
  color:#fff;font-family:var(--font-mono);font-size:.72rem;font-weight:600;
  padding-right:.6rem;min-width:3rem;transition:width 1.4s cubic-bezier(.3,.7,.3,1);
}
.fill-slate{background:var(--slate)}
.fill-teal{background:linear-gradient(90deg,var(--strand-deep),var(--strand))}
.hr-explainer p{font-size:.92rem;margin:0}

/* ---------- trial design svg ---------- */
.svg-design .d-pop{fill:#fff;stroke:var(--hairline);stroke-width:1.2}
.svg-design .d-rand{fill:var(--strand-wash);stroke:rgba(14,149,148,.45);stroke-width:1.4}
.svg-design .d-arm{fill:#fff;stroke-width:1.4}
.d-arm-a{stroke:var(--strand)}
.d-arm-b{stroke:var(--slate);stroke-dasharray:5 4}

/* ---------- met-explainer ---------- */
.met-explainer{
  background:linear-gradient(135deg,var(--strand-wash),#F2F9F9);
  border:1px solid rgba(14,149,148,.3);border-radius:var(--radius);
  padding:clamp(1.3rem,2.6vw,1.8rem);margin:0 0 1.6rem;
}
.met-explainer h4{color:var(--strand-deep)}
.met-explainer p{font-size:.95rem;margin:0;max-width:60rem}

/* ---------- known/unknown ledger ---------- */
.card-known{border-top:3px solid var(--strand)}
.card-unknown{border-top:3px solid var(--warm)}
.ledger-tag{font-size:.7rem}
.ledger{list-style:none;padding:0;margin:0}
.ledger li{
  position:relative;padding-left:1.7rem;margin-bottom:.65rem;font-size:.94rem;
}
.ledger li::before{
  content:"";position:absolute;left:0;top:.34em;width:14px;height:14px;border-radius:50%;
  background:var(--strand-wash) center/9px no-repeat url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 12 12'%3E%3Cpath d='M2.5 6.4l2.4 2.3 4.6-5.4' fill='none' stroke='%230E9594' stroke-width='2' stroke-linecap='round' stroke-linejoin='round'/%3E%3C/svg%3E");
  border:1px solid rgba(14,149,148,.4);
}
.ledger-x li::before{
  background:var(--warm-wash) center/9px no-repeat url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 12 12'%3E%3Cpath d='M6 3v4' stroke='%23B4552D' stroke-width='2' stroke-linecap='round'/%3E%3Ccircle cx='6' cy='9.4' r='1.1' fill='%23B4552D'/%3E%3C/svg%3E");
  border-color:rgba(217,126,54,.45);
}
.ledger-board{
  margin-top:2.4rem;background:var(--panel);border:1px solid var(--hairline);
  border-radius:var(--radius);padding:clamp(1.4rem,3vw,2.2rem);box-shadow:var(--shadow-lg);
}
.ledger-h{font-size:.78rem;font-family:var(--font-mono);letter-spacing:.14em;text-transform:uppercase;margin-bottom:1rem}
.ledger-yes{color:var(--strand-deep)}
.ledger-no{color:var(--warm-deep)}

/* ---------- firsts ---------- */
.firsts{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:1.2rem;margin-bottom:2.2rem}
.first{
  background:var(--panel);border:1px solid var(--hairline);border-radius:var(--radius);
  padding:1.3rem;box-shadow:var(--shadow);display:flex;gap:1rem;align-items:flex-start;
}
.first-num{font-size:1.6rem;color:var(--warm);line-height:1;font-weight:600}
.first p{font-size:.9rem;margin:0}

/* ---------- program table ---------- */
.card-program{overflow:hidden}
.prog-table{width:100%;border-collapse:collapse;font-size:.82rem;margin-top:.6rem}
.prog-table th{
  text-align:left;font-family:var(--font-mono);font-size:.66rem;letter-spacing:.1em;
  text-transform:uppercase;color:var(--muted);border-bottom:1.5px solid var(--hairline);
  padding:.4rem .5rem .55rem;
}
.prog-table td{padding:.5rem;border-bottom:1px solid var(--hairline);vertical-align:top;color:var(--ink-2)}
.prog-table td.mono{font-size:.8rem;font-weight:600;color:var(--ink)}
.prog-table tr:last-child td{border-bottom:none}
.prog-win td{background:var(--strand-wash)}
.prog-table .tag{font-size:.56rem;margin-left:.4rem}

/* ---------- timeline ---------- */
.timeline{
  list-style:none;padding:0;margin:2rem 0 0;position:relative;
  display:grid;grid-template-columns:repeat(8,minmax(0,1fr));gap:0;
}
.timeline::before{
  content:"";position:absolute;left:0;right:0;top:11px;height:2px;
  background:linear-gradient(90deg,var(--strand) 0 62%,var(--warm-soft) 62% 100%);
}
.timeline li{position:relative;padding:2.4rem .9rem 0 0;font-size:.8rem;line-height:1.5}
.timeline li::before{
  content:"";position:absolute;top:4px;left:0;width:16px;height:16px;border-radius:50%;
  border:3px solid var(--paper);
}
.tl-done::before{background:var(--strand)}
.tl-now::before{background:var(--warm);box-shadow:0 0 0 5px var(--warm-wash)}
.tl-next::before{background:#fff;border:3px dashed var(--warm);width:16px;height:16px}
.tl-when{display:block;font-weight:600;color:var(--ink);margin-bottom:.35rem;font-size:.78rem}
.tl-now .tl-when{color:var(--warm-deep)}
.timeline p,.timeline div{color:var(--ink-2)}
.tl-next div{color:var(--muted)}

/* ---------- sources ---------- */
.chapter-sources{border-top:1px solid var(--hairline)}
.src-list{padding-left:0;counter-reset:src;list-style:none;display:grid;gap:1rem}
.src-list li{
  counter-increment:src;position:relative;padding:1rem 1.2rem 1rem 3.6rem;
  background:var(--panel);border:1px solid var(--hairline);border-radius:12px;
  font-size:.88rem;line-height:1.6;color:var(--ink-2);box-shadow:var(--shadow);
}
.src-list li::before{
  content:counter(src);position:absolute;left:1.1rem;top:1.05rem;
  font-family:var(--font-mono);font-size:.95rem;font-weight:600;color:var(--strand);
}
.src-list li{overflow-wrap:break-word}
.src-list a{overflow-wrap:anywhere}
.src-list li:target{border-color:var(--strand);box-shadow:0 0 0 3px var(--strand-wash),var(--shadow)}
.disclaimer{
  margin-top:2.4rem;background:var(--warm-wash);border:1px solid rgba(217,126,54,.3);
  border-radius:var(--radius);padding:clamp(1.3rem,2.6vw,1.9rem);
}
.disclaimer h4{color:var(--warm-deep)}
.disclaimer p{font-size:.9rem;margin:0;color:#6B4A2E}

/* ---------- footer ---------- */
.footer{border-top:1px solid var(--hairline);background:#0C1B2A;color:#8FA5B8;position:relative;z-index:1}
.footer-inner{
  max-width:var(--wrap);margin:0 auto;padding:2.4rem clamp(1.2rem,4vw,2.4rem);
  display:flex;gap:1.4rem;align-items:flex-start;
}
.footer .brand-mark{color:var(--strand-bright);width:30px;height:30px;flex:none;margin-top:.2rem}
.footer p{font-size:.8rem;margin:0;line-height:1.6;max-width:52rem}
.footer strong{color:#E6EEF4}
.to-top{margin-left:auto;flex:none;color:var(--strand-bright);border-color:rgba(20,184,196,.4);font-size:.82rem;white-space:nowrap}

/* ---------- terms & tooltip ---------- */
.term{
  background:none;border:none;padding:0;margin:0;cursor:help;
  color:inherit;font:inherit;font-weight:600;
  border-bottom:1.5px dotted var(--strand);transition:color .15s,border-color .15s;
}
.term:hover,.term:focus-visible{color:var(--strand-deep);border-bottom-style:solid;outline:none}
.tooltip{
  position:fixed;z-index:80;max-width:19rem;
  background:var(--ink);color:#E6EEF4;border-radius:12px;
  padding:.85rem 1rem;box-shadow:var(--shadow-lg);
  font-size:.82rem;line-height:1.55;pointer-events:none;
  opacity:0;transform:translateY(6px);transition:opacity .18s,transform .18s;
}
.tooltip.show{opacity:1;transform:translateY(0)}
.tooltip-term{font-family:var(--font-mono);font-size:.68rem;letter-spacing:.12em;text-transform:uppercase;color:var(--strand-bright);margin-bottom:.35rem}
.tooltip::after{
  content:"";position:absolute;left:var(--arrow-x,50%);bottom:-6px;transform:translateX(-50%);
  border:6px solid transparent;border-top-color:var(--ink);border-bottom:none;
}

/* ---------- reveal animations ---------- */
.reveal{opacity:0;transform:translateY(26px);transition:opacity .7s ease,transform .7s cubic-bezier(.22,.8,.3,1)}
.reveal.in{opacity:1;transform:none}
.reveal[data-stagger] > *{opacity:0;transform:translateY(18px);transition:opacity .6s ease,transform .6s cubic-bezier(.22,.8,.3,1)}
.reveal.in[data-stagger] > *{opacity:1;transform:none}

/* helix drift */
.helix{animation:helixDrift 26s linear infinite}
.helix-2{animation-duration:34s;animation-direction:reverse}
@keyframes helixDrift{from{transform:translateX(0)}to{transform:translateX(-220px)}}

/* ---------- responsive ---------- */
@media (max-width:1000px){
  .brand-text em{display:none}
  .brand-text{font-size:.95rem}
  .topnav{margin-left:auto;-webkit-mask-image:linear-gradient(90deg,transparent,#000 5%,#000 95%,transparent);mask-image:linear-gradient(90deg,transparent,#000 5%,#000 95%,transparent)}
  .topnav a{padding:.4rem .6rem}
  .timeline{grid-template-columns:repeat(4,minmax(0,1fr))}
  .timeline::before{display:none}
  .timeline li{padding-top:1.8rem}
  .timeline li::before{top:0}
  .pipe{grid-template-columns:repeat(3,minmax(0,1fr))}
}
@media (max-width:820px){
  .grid-2,.grid-3{grid-template-columns:minmax(0,1fr)}
  .firsts{grid-template-columns:minmax(0,1fr)}
  .wanted{grid-template-columns:1fr;justify-items:center}
  .wanted-copy{text-align:left}
  .statcards{grid-template-columns:minmax(0,1fr) minmax(0,1fr)}
  .ch-num{position:static;display:block;font-size:2rem;border:none;color:var(--strand);margin-bottom:.4rem}
  .hero-stats{flex-direction:column}
  .hstat{border-right:none;border-bottom:1px solid var(--hairline);padding:1rem 1.2rem;display:flex;align-items:baseline;gap:1rem}
  .hstat:last-child{border-bottom:none}
  .hstat-label{margin-top:0}
  .pipe{grid-template-columns:minmax(0,1fr) minmax(0,1fr)}
}
@media (max-width:560px){
  body{font-size:1rem}
  .pipe{grid-template-columns:minmax(0,1fr)}
  .statcards{grid-template-columns:minmax(0,1fr)}
  .hr-bar-row{grid-template-columns:7rem minmax(0,1fr);gap:.6rem}
  .topdate{display:none}
  .topbar{gap:1rem}
  .brand-text{display:none}
  .timeline{grid-template-columns:minmax(0,1fr)}
  .timeline li{padding:0 0 1.4rem 2rem}
  .timeline li::before{top:2px}
  .src-list li{padding-left:3rem}
  .footer-inner{flex-direction:column}
  .to-top{margin-left:0}
}

/* ---------- reduced motion ---------- */
@media (prefers-reduced-motion:reduce){
  html{scroll-behavior:auto}
  .reveal,.reveal[data-stagger]>*{opacity:1!important;transform:none!important;transition:none!important}
  .helix,.scrollcue svg{animation:none}
  .pipe-fill{transition:none}
  .hr-fill{transition:none}
}